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Research

We have embarked on a journey to unravel the broken symmetries in living matter. 
The sections below are organized in order of decreasing spatial scale - from the organismal level of echinoderm embryos, down to the cellular level, and lastly to the intracellular level.

Chiral symmetry breaking: nonreciprocal matter

  • Odd dynamics of living chiral crystals (Nature 2022)
  • Excitable nonreciprocal solids
  • Boundary-induced melting
  • Nonreciprocal phase transitions
  • Active crystallography - dispersion relations

Spatiotemporal symmetry breaking: protein patterns

  • How cells perform computation (Nat. Phys. 2021)
  • Topological defects as organizers of biochemical and physical activity (Nat. Phys. 2020, PNAS 2021)
  • Optogenetic and light-induced cortical excitability
  • Machine learning energetic costs of pattern formation and efficiency of information transport in living systems (arXiv 2023)

Time-reversal symmetry breaking: thermodynamic arrow of time

  • Broken detailed balance (Science 2016)
  • Thermodynamic uncertainty relation (Nat. Comm. 2019)
  • Irreversibility and KL divergence (arXiv 2021)
  • Probability "angular momentum" and correlation functions (Nat. Nano 2023)
  • Machine learning - invariant scattering + recurrent neural networks
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